Product Description: McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent[1][2].
Applications: Cancer-programmed cell death
Formula: C49H76N6O11
References: [1]Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res. 2009 Mar 15;69(6):2358-2364./[2]Jianmin Fang, et al. Anti-her2 antibody and conjugate thereof. US 20160304621 A1.
CAS Number: 863971-19-1
Molecular Weight: 925.16
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Drug-Linker Conjugates for ADC
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