MELK-8a (hydrochloride), CAS 2096992-20-8

Formulation: A solid

Formal Name: 1-methyl-4-[4-[4-[3-(4-piperidinylmethoxy)-4-pyridinyl]-1H-pyrazol-1-yl]phenyl]-piperazine, monohydrochloride

Purity: ≥95%

Formula Markup: C25H32N6O • HCl

Formula Weight: 469

Shelf life (days): 1460

CAS Number: 2096992-20-8

Notes: MELK-8a is an inhibitor of maternal embryonic leucine zipper kinase (MELK; IC50 = 0.002 µM).{67095} It is selective for MELK over FLT3, haspin, KIT, and PDGFRα, (IC50s = 0.18, 0.19, >10, and 0.42 µM, respectively), as well as a panel of 456 kinases at 1 µM. MELK-8a inhibits the proliferation of MDA-MB-468 and MCF-7 breast cancer cells (IC50s = 0.11 and 3.68 µM).

• SKU: CAY37025-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37025-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK
• Application: Reinstoffe