MK-0591, CAS 136668-42-3

Formulation: A solid

Formal Name: 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(2-quinolinylmethoxy)-1H-indole-2-propanoic acid

Purity: ≥98%

Formula Markup: C34H35ClN2O3S

Formula Weight: 587,2

Shelf life (days): 1460

CAS Number: 136668-42-3

Notes: MK-0591 is an inhibitor of 5-lipoxygenase-activating protein (FLAP; IC50 = 1.6 nM for the human enzyme).{66184} It inhibits leukotriene B4 (LTB4; Item No. 20110) biosynthesis in isolated rat neutrophils stimulated with the calcium ionophore A23187 (Item No. 11016; IC50 = 6 nM) but does not inhibit 5-lipoxygenase (5-LO) in a cell-free assay (IC50 = > 4 µM for the rat enzyme). MK-0591 (0.3 and 1 mg/kg) prevents increases in airway resistance and decreases in dynamic compliance in Ascaris antigen-induced squirrel monkeys. It decreases proteinuria and reduces decreases in renal LTC4 synthase activity in a rat model of glomerulonephritis induced by nephrotoxic rabbit serum when administered at a dose of 60 mg/kg.{66185} MK-0591 (8 µM) also induces apoptosis in LNCaP prostate cancer cells.{66186}

• SKU: CAY37322-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37322-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe