ML-162, CAS 1035072-16-2

Formulation: A crystalline solid

Formal Name: α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide

Purity: ≥95%

Formula Markup: C23H22Cl2N2O3S

Formula Weight: 477,4

Shelf life (days): 1460

CAS Number: 1035072-16-2

Notes: ML-162 is an inhibitor of glutathione peroxidase 4 (GPX4).{57628} It decreases GPX4 levels in MDA-MB-231 breast cancer cells, as well as the viability of BT-549 breast cancer cells, an effect that is enhanced by α-eleostearic acid (9(Z),11(E),13(E)-octadecatrienoic acid; Item No. 10008349). ML-162 is also selectively lethal to mutant RAS oncogene-expressing cells (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type RAS-expressing BJeH cells, respectively).{33150}

• SKU: CAY20455-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 20455-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK