Formulation: A solid
Formal Name: 2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydro-N-(phenylmethyl)-4-quinazolinamine, monohydrochloride
Purity: ≥98%
Formula Markup: C23H24N4O • HCl
Formula Weight: 408,9
Shelf life (days): 1460
CAS Number: 2070015-13-1
Notes: ML-241 is an ATP-competitive inhibitor of the ATPase p97 (IC50 = 0.11 µM) that is selective for the D2 domain of p97.{28269,28270} It disrupts the endoplasmic reticulum-associated degradation (ERAD) pathway, preventing the degradation of p97-dependent proteasome substrates in a reporter assay using HeLa cells (IC50 = 3.5 µM) and inducing the accumulation of ubiquitin conjugates in the nuclear plus membrane and cytosolic compartments of SW403 colon cancer cells when used at concentrations of 5 and 10 µM.{28269} Unlike the p97 inhibitor ML-240, ML-241 does not induce autophagy or apoptosis in, or inhibit the proliferation of, HCT15 and SW403 cancer cells.
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