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Background: ML-161 is thought to act allosterically. ML-161 inhibits thrombin-induced platelet activation.
Biological Activity: ML-161 is an antagonist of the protease-activated receptor 1 (PAR1), that inhibits thrombin and SFLLN-induced platelet activation. ML-161 dose dependently inhibits SFLLN-induced expression of P-selectin with an IC50 of 0.26 µM.
CAS Number: 423735-93-7
Description: Allosteric and reversible inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 µM for the inhibition of platelet P-selectin expression on human platelets).
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: PAR-1
Biosafety Level: Not applicable (BSL-1)
References: Dockendorff, C., et al. 2012. ACS Med. Chem. Lett. 3: 232-237
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