MLN9708, CAS 1201902-80-8

Formulation: A crystalline solid

Formal Name: 4-carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid

Purity: ≥95%

Formula Markup: C20H23BCl2N2O9

Formula Weight: 517,1

Shelf life (days): 1460

CAS Number: 1201902-80-8

Notes: MLN9708 is a prodrug form of the proteasome inhibitor MLN2238 (Item No. 18385).{31628,31627} It is converted to MLN2238 via hydrolysis in the plasma.{31628} MLN9708 inhibits the 20S proteasome (IC50 = 8.4 nM for the human enzyme) and binds to caseinolytic protease P (Kd = 7,300 nM for the S. aureus enzyme).{57957,58924} It inhibits the proliferation of RPMI-8226, U266B, and ARH-77 multiple myeloma cells with IC50 values of 49.4, 67, and 43.5 nM, respectively.{57957}

• SKU: CAY18386-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 18386-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK