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CAS Number: 726169-73-9
Description: Mocetinostat selectively inhibits histone deacetylases (HDACs) 1-3 and 11 at submicromolar concentrations. It blocks cancer cell proliferation in vitro and has significant antitumor activity in vivo. Mocetinostat induces hyperacetylation of histones, causes expression of the tumor suppressor protein p21(WAF1/CIP1), and inhibits proliferation of human cancer cells growing in culture.
Format: A crystalline solid
Purity: ≥99%
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Zhou, N., et al. J. Med. Chem. 51: 4072-4075 (2008).
2. Raeppel, S., et al. Bioorg. Med. Chem. Lett. 19: 644-649 (2009).
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