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Biological Activity: Mocetinostat (MGCD0103) inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 0.15 µM, 0.29 µM and 1.66 µM, respectively.
CAS Number: 726169-73-9
Description: Mocetinostat (MGCD0103) is an HDAC inhibitor. It was shown to induce hyperacetylation of histones resulting in cancer cell selective apoptosis, and cause cell cycle blockade in various human cancer cell lines in a dose-dependent manner. Mocetinostat inhibites growth of human tumor xenografts in nude mice in a dose-dependent manner and its antitumor activity correlates with induction of histone acetylation in tumors.
Format: A crystalline solid
Purity: ≥99% by HPLC
Solubility: Solubility in DMSO is 13 mg/ml, and in water and ethanol is < 1 mg/ml. DMSO stock solutions are stable up to one week at 4°C or up to a month at -70°C. Do not store aqueous solutions for more than one day.
Storage Stability: Store at or below -20°C. Solid form is stable at least 2 years from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Foumel, M., et al., Mol Cancer Ther. 2008;7:759-768.
2. Duque-Afonso, J., et al. Oncogene 2011. July;30:3062-72.
3. Munkacsi, A.B., et al. J. Biol. Chem. 2011. July;286:23842-51.
4. Xu, X., et al. PLoS ONE. February 2011. 6:e17138.
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