Formulation: A solid
Formal Name: (3S)-2-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid
Purity: ≥95%
Formula Markup: C25H30N2O7
Formula Weight: 470,5
Shelf life (days): 1460
CAS Number: 103775-14-0
Notes: Moexiprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 2.1 nM) and an active metabolite of the prodrug moexipril (Item No. 21255).{33383} It is formed from moexipril in vivo by side chain ester hydrolysis.{33382} Moexiprilat (10 nM) prevents the estrone- or angiotensin II-stimulated proliferation of primary neonatal rat cardiac fibroblasts.{68435} It reduces mean arterial blood pressure and increases the levels of atrial natriuretic peptide, a marker of hypertension, in ovariectomized mice when administered at a dose of 50 mg/kg per day.{68436}
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