Formulation: A solid
Formal Name: 4-fluoro-βE-(fluoromethylene)-benzenebutanamine, monohydrochloride
Purity: ≥95%
Formula Markup: C11H13F2N • HCl
Formula Weight: 233,7
Shelf life (days): 1460
CAS Number: 120635-25-8
Notes: Mofegiline is an inhibitor of monoamine oxidase B (MAO-B; IC50 = 3.6 nM for the rat brain mitochondrial enzyme).{60769} It is selective for MAO-B over MAO-A (IC50 = 680 nM). Mofegiline also inhibits vascular adhesion protein-1 (VAP-1), also known as semicarbazide-sensitive amine oxidase (SSAO), an enzyme that has roles in leukocyte adhesion and transmigration, with an IC50 value of 20 nM for the human enzyme.{60770} It reduces MPTP-induced decreases in striatal levels of dopamine, dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) in mice when administered at a dose of 1.25 mg/kg.{60769} Mofegiline (5 mg/kg) also inhibits LPS-induced increases in bronchoalveolar lavage fluid (BALF) levels of TNF-α in transgenic mice overexpressing VAP-1.
English
Deutsch
