Formulation: A solid
Purity: ≥90%
Formula Markup: C7H11NO5
CAS Number: 1188-37-0
Notes: N-acetyl-L-Glutamic acid (NAG) is an endogenous metabolite.{69606} It is an allosteric activator of mitochondrial carbamoyl phosphate synthetase, an enzyme involved in the urea cycle, and the first intermediate in arginine biosynthesis in bacteria.{69616,69617,69618} NAG inhibits human liver NAG synthase (NAGS; Ki = 0.25 mM).{69619} It also inhibits several enzymes involved in mitochondrial bioenergetics, including isocitrate dehydrogenase 2 (IDH2), mitochondrial complex IV, also known as cytochrome c oxidase, and glutamate dehydrogenase (GDH), in rat brain mitochondrial preparations when used at a concentration of 1 mM.{69620} Increased urine levels of NAG are associated with mutations in the gene encoding aminoacylase-1 (ACY1), an enzyme involved in the hydrolysis of N-acetylated proteins.{69606}
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