Product Type: Antagonist
CAS No.: 58895-64-0
MolecularFormula: C21H25NO3 • HCl
Molecular Weight: 375,9
Source: Synthetic
Purity: >98% (HPLC); NMR (Conforms)
Solubility: May be dissolved in water (25 mg/ml)
Appearance: White powder
PubChem CID: 5388881
Scientific Background: An opiod antagonist with a very similar activity profile to naloxone, however, it displays slower onset and longer duration of action (1). It antagonizes the effects of salvinorin (2) (delta-agonist) as well as herkinorin (3) (mu-agonist). Has been used as a therapeutic for treatment of alcohol dependence (4).
References: 1.Osborn, M.D., et al. (201) Life Sci. 86:624.2. Butelman E.R., et al. (2009) J. Pharmacol. Exp. Ther. 328:588.3.Butelman E.R., et al. (2008) J. Pharmacol. Exp. Ther. 327:154.4.Soyka M., and Rosner S. (2008) Curr. Drug Abuse Rev. 1:280.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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