Nedometinib, CAS 2252314-46-6

Formulation: A solid

Formal Name: 2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

Purity: ≥98%

Formula Markup: C17H16FIN4O3

Formula Weight: 470,2

Shelf life (days): 1460

CAS Number: 2252314-46-6

Notes: Nedometinib is a MEK1 inhibitor (IC50 = 135 nM).{49842} It is selective for MEK1 over a panel of 44 receptors, ion channels, and enzymes at 10 µM, as well as a panel of an additional 150 kinases. Nedometinib (0.1-10 µM) decreases phosphorylation of ERK in malignant peripheral nerve sheath tumor cells. Topical application of nedometinib (0.1-2.3%) reduces the total number of tumors in a mouse model of cutaneous squamous cell carcinoma induced by UV radiation.

• SKU: CAY40465-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40465-500
• Package Unit: 500 µg
• Quantity Unit: STK