Formulation: A crystalline solid
Formal Name: 6-(4-ethoxyphenyl)-4-methoxy-2-pyridinecarboxylic acid, 1-methylethyl ester
Purity: ≥98%
Formula Markup: C18H21NO4
Formula Weight: 315,4
Shelf life (days): 730
CAS Number: 2598242-66-9
Notes: NG-497 is an inhibitor of adipose triglyceride lipase (ATGL; IC50 = 1 µM), also known as patatin-like phospholipase domain-containing protein 2 (PNPLA2).{69125} It is selective for ATGL over PNPLA1, PNPLA3, PNPLA4, and PNPLA5 at 100 µM. NG-497 selectively inhibits the triacylglycerol hydrolase activity of human and rhesus monkey ATGL over rat, dog, and marmoset ATGL, which it inhibits by less than 20% at 50 µM, and over mouse, goat, and pig ATGL at which it is inactive at 50 µM. NG-497 inhibits fatty acid and glycerol release induced by isoproterenol (Item No. 15592) in human Simpson-Golabi-Behmel syndrome (SGBS) adipocytes (IC50 = 1.5 µM for both). It also inhibits forskolin-induced fatty acid release in primary human adipocytes.
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