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Biological Activity: Novo-TRX has been shown to inhibit bacterial DNA gyrase activity with an IC50 of 0.6 =uM.
CAS Number: 1476-53-5
Description: Novobiocin is an aminocoumarin antibiotic that is produced by Streptomyces niveus. Along with other aminocoumarin antibiotics, novobiocin is a very potent inhibitor of bacterial DNA gyrase. It works by targeting the GyrB subunit of the enzyme involved in energy transduction. Novo-TRX is Texas Red-labeled novobiocin, which can be used as a fluorescence probe in assays for screening DNA gyrase inhibitors.
Format: A red aqueous solution
Purity: ≥93% by HPLC
Storage Stability: Store at or below -20°C and avoid multiple freeze-thaw cycles to prevent decomposition.
Supplied As: 10 µM solution in anhydrous DMSO
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Lamour V, et al., J Biol Chem. 2002 May 24;277(21):18947-53.
2. Glaser BT, et al., J Biomol Screen. 2011 Feb;16(2):230-8.
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