NSC-632839, CAS 157654-67-6

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Applications: Useful for non-specific inhibition of ubiquitin-like isopeptidases for cell biology and drug discovery studies.

CAS Number: 157654-67-6

Description: NSC 632839 hydrochloride is an inhibitor of USP (ubiquitin isopeptidase) activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation.

Format: Yellow powder

Purity: >98% by HPLC.

Solubility: Soluble in DMSO (8 mg/ml)

Storage Stability: Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 month.

Warnings: Protect from moisture.

Biosafety Level: Not applicable (BSL-1)

References: 1. Aleo, E. et al. Identification of New Compounds That Trigger Apoptosome-Independent Caspase Activation and Apoptosis. Cancer Res. 2006. 66:9235.
2. Nicholson, B. et al. Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities. Protein Sci. 2008. 17:1035

• SKU: BPS27709-2
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 27709-2
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK