Formulation: A solid
Formal Name: 5-[4-[(2S,5S)-5-[(4-chlorophenyl)methyl]-2-methyl-4-morpholinyl]-1-piperidinyl]-1H-1,2,4-triazol-3-amine
Purity: ≥98%
Formula Markup: C19H27ClN6O
Formula Weight: 390,9
Shelf life (days): 1460
CAS Number: 2088453-21-6
Notes: OATD-01 is an inhibitor of chitotriosidase 1 (CHIT1) and acidic mammalian chitinase (CHIA), also known as AMCase (IC50s = 23 and 9 nM, respectively).{61814} It is selective for CHIT1 and CHIA over a panel of 98 enzymes at 10 µM. OATD-01 (30 and 100 mg/kg) reduces the degree of lung fibrosis and plasma chitinolytic activity in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).