Formulation: A solid
Formal Name: (2S)-2-[[(2R)-2-[[2-[[3,3-dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-butanoic acid
Purity: ≥90%
Formula Markup: C37H48N4O8S2
Formula Weight: 740,9
Shelf life (days): 1460
CAS Number: 501692-44-0
Notes: Odevixibat is an inhibitor of the sodium/bile acid and sulfated solute cotransporter (ASBT; IC50 = 0.16 nM).{67170} It inhibits intestinal reabsorption of [75Se]homotaurocholic acid (75SeHCAT) by 74% in ApoE-/- mice when administered at a dose of 0.156 µmol/kg. Formulations containing odevixibat have been used in the treatment of pruritis in patients with progressive familial intrahepatic cholestasis, an inborn error of metabolism characterized by mutations in various genes involved in bile production and transport, including ATP8B1 and ABCB11.
English
Deutsch
