Opicapone, CAS 923287-50-7

Formulation: A solid

Formal Name: 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-1,2-benzenediol

Purity: ≥98%

Formula Markup: C15H10Cl2N4O6

Formula Weight: 413,2

Shelf life (days): 1460

CAS Number: 923287-50-7

Notes: Opicapone is a peripherally selective inhibitor of catechol-O-methyltransferase (COMT).{62240} It inhibits COMT activity in rat liver, but not brain, homogenates (ED50 = 1.05 mg/kg). Opicapone (3 mg/kg) increases plasma levels of L-DOPA (Item No. 13248) and reduces plasma levels of 3-O-methyl-DOPA (3-OMD) when administered in combination with benserazide (Item No. 20298) and L-DOPA.{62241} Formulations containing opicapone have been used as adjuvants in the treatment of “off” episodes associated with Parkinson’s disease.

• SKU: CAY34253-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 34253-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK