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Applications: Useful for inhibition of USP7 and USP47 activity.
CAS Number: 1247819-59-5
Description: P22077 is a cell permeable inhibitor of the ubiquitin-specific protease USP7 (IC50=8.6 µM), and the closely related deubiquitinase (DUB) USP47. P22077 showed weak or no inhibition (EC50 >50µM) towards a panel of 14 isopeptidases and other proteases. Treatment of cells with P22077 (20-40 µM) causes an accumulation of K48-linked ubiquitinated species, and down regulation of the USP7 targets HDM2 and claspin.
Format: Light powder
Purity: ≥98% by HPLC.
Solubility: Soluble in DMSO
Storage Stability: Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 month.
Warnings: Protect from moisture.
Biosafety Level: Not applicable (BSL-1)
References: 1. Altun, M., et al. , Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem Biol, 2011. 18(11): p. 1401-12.
2. Tian, X., et al., Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format. Assay Drug Dev Technol, 2011. 9(2): p. 165-73.
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