PAC-1 , CAS 315183-21-2

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CAS Number: 315183-21-2

Description: Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 µM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 µM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 µM respectively). PAC-1 had an IC50 value of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue IC50 values of 3.2-8.5 µM were observed

Format: A crystalline solid

Purity: ≥99%

Solubility: Soluble to 75 mM in 1eq. HCl and to 100 mM in DMSO

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Biosafety Level: Not applicable (BSL-1)

References: 1. Putt et al. (2006). Nat.Chem.Biol. 2 543. PMID: 16936720.
2. Peterson et al. (2009). J.Med.Chem. 52 5721. PMID: 19708658.

• SKU: BPS27043
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 27043
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK