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CAS Number: 404950-80-7
Description: Panobinostat, also known as LBH-589, is a highly active, non-selective HDAC inhibitor. IC50's against HDAC s 1-9 range between 3 - 61 nM except for a slightly higher IC50 value of 248 nM for HDAC 8. Panobinostat inhibits tumor cell proliferation and induces apoptosis in breast cancer and T cell lymphoma cells. In addition to its tumor-suppressive activities, panobinostat induces histone H3K9 and histone H4K8 acetylation and decreases the level of c-Myc expression.
Format: Yellow solid
Purity: ≥99%
Solubility: Soluble in DMSO at 200 mg/ml; soluble in ethanol at 5 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-50 µM buffers, serum, or other additives may increase or decrease the aqueous solubility.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Zhou Q, et al. H Cancer Biol Ther 2007; 6(1):64-69.
2. Ellis L, Pan Y et al. Clin Cancer Res 2008; 14(14):4500-4510.
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