PD 0325901, CAS 391210-10-9

Formulation: A crystalline solid

Formal Name: N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide

Purity: ≥90%

Formula Markup: C16H14F3IN2O4

Formula Weight: 482,2

Shelf life (days): 1460

CAS Number: 391210-10-9

Notes: The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors.{6694,16830} PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM.{16877} Suppression of ERK activation with 1 µM PD 0325901 combined with 3 µM CHIR99021 (a glycogen synthase kinase 3 inhibitor) prevents cell differentiation and sustains self renewal of mouse embryonic stem cells for at least eight passages.{16878}

• SKU: CAY13034-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 13034-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK