Perindoprilat, CAS 95153-31-4

Formulation: A crystalline solid

Formal Name: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid

Purity: ≥95%

Formula Markup: C17H28N2O5

Formula Weight: 340,4

Shelf life (days): 1460

CAS Number: 95153-31-4

Notes: Perindoprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 1.05 nM) and an active metabolite of the ACE inhibitor prodrug perindopril (Item No. 20796).{51325} It reduces expression of the mRNA encoding VEGF in KB oral squamous cell carcinoma cells when used at concentrations of 1 and 2 µM.{51326} Perindoprilat, in combination with bradykinin, induces endothelium-dependent relaxation in isolated dog basilar and coronary arteries with 30% maximum induction (IC30) values of 0.46 and 1.15 µM, respectively.{51327} In vivo, perindoprilat (20 µg/kg) reverses or prevents restricted oxygen-induced decreases in mean blood pressure, renal blood flow, and renal vascular resistance, as well as increases in the urine flow rate in an acute hypoxemia-induced rabbit model of renal hypoperfusion.{51328}

• SKU: CAY17574-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 17574-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK