Formulation: A solid
Formal Name: 5-(4-chlorophenyl)-3,3′-bipyridine]-6,6′-diamine
Purity: ≥98%
Formula Markup: C16H13ClN4
Formula Weight: 296,8
Shelf life (days): 1460
CAS Number: 1811510-56-1
Notes: PF-6260933 is an inhibitor of mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4; IC50 = 3.7 nM).{61945} It is selective for MAP4K4 over a panel of 41 kinases at 1 µM but also inhibits TRAF2- and NCK-interacting kinase (TNIK) and misshapen-like kinase 1 (MINK1; IC50s = 15 and 8 nM, respectively). PF-6260933 inhibits the replication of CMV strains AD169 and Merlin(R1111) strains in human foreskin fibroblast (HFF) cells (EC50s = 9.6 and 13.3 µM, respectively).{61946} It inhibits collagen- or thrombin-induced aggregation of isolated human platelets by 70.9 and 61.2%, respectively, when used at a concentration of 20 µM.{61947} It decreases plaque formation in ApoE-/- mice fed a Western diet in a model of atherosclerosis when administered at a dose of 10 mg/kg.{61948} PF-6260933 (15 mg/kg) decreases LPS-induced increases in TNF-α levels in wild-type mice and fasting blood glucose levels in ob/ob mice.{61945}
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