Formulation: A solid
Formal Name: 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[2-(1-methylethoxy)-5-(1-piperazinylmethyl)phenyl]-4(3H)-quinazolinone
Purity: ≥98%
Formula Markup: C35H41ClN6O4
Formula Weight: 645,2
Shelf life (days): 1460
CAS Number: 1538593-71-3
Notes: Piperazine erastin is an inducer of ferroptosis.{43385,29243} It inhibits glutamate release in human CCF-STTG1 astrocytoma cells (IC50 = 0.8 µM), indicating inhibition of the system xc- cystine/glutamate transporter, and decreases glutathione (GSH) levels in HT-1080 fibrosarcoma cells when used at a concentration of 10 µM. Piperazine erastin inhibits the growth of BJeLR cells overexpressing the H-Ras activating mutation H-RasG12V (IC50 = 0.3 µM).{43385} It increases hepatic mRNA expression of the gene encoding Cox-2 and prevents tumor formation in an HT-1080 mouse xenograft model when administered at a dose of 60 mg/kg.{29243}
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