Pirtobrutinib, CAS 2101700-15-4

Formulation: A solid

Formal Name: 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1S)-2,2,2-trifluoro-1-methylethyl]-1H-pyrazole-4-carboxamide

Purity: ≥98%

Formula Markup: C22H21F4N5O3

Formula Weight: 479,4

Shelf life (days): 1460

CAS Number: 2101700-15-4

Notes: Pirtobrutinib is an inhibitor of Bruton’s tyrosine kinase (BTK).{66150} It inhibits wild-type and mutant BTK (IC50s = 10-100 and C481S, respectively). It is selective for BTK over EGFR (IC50 = 1-10 µM). Pirtobrutinib decreases the number of Ki67-positive cells, a marker of cell proliferation, in MEC-1 chronic lymphocytic leukemia (CLL) mouse xenograft models using MEC-1 cells that express either wild-type BTK or BTKC481S.{66149}

• SKU: CAY36775-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36775-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK
• Application: Reinstoffe