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CAS Number: 344458-15-7
Description: A cell-permeable, water-soluble, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 µM). Does not act as an antioxidant at higher concentrations (1 µM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke.
Format: White to light brown powder.
Purity: ≥98%
Solubility: Soluble to 100 mM in water and to 100 mM in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Warnings: Hygroscopic. Protect from Moisture. Protect from light.
Biosafety Level: Not applicable (BSL-1)
References: Huang, S.H., et al. Oncol Rep. 2008 Sep;20(3):567-72.