PKCβ Inhibitor, CAS 257879-35-9

Formulation: A solid

Formal Name: 3-[1-[3-(1H-imidazol-1-yl)propyl]-1H-indol-3-yl]-4-(phenylamino)-1H-pyrrole-2,5-dione

Purity: ≥98%

Formula Markup: C24H21N5O2

Formula Weight: 411,5

Shelf life (days): 1460

CAS Number: 257879-35-9

Notes: PKCβ inhibitor is an inhibitor of PKCβ1 and PKCβ2 (IC50s = 21 and 5 nM, respectively).{67060} It is selective for PKCβ1 and PKCβ2 over PKCα, PKCε, and PKCγ (IC50s = 331, 2,807, and >1,000 nM, respectively), as well as JAK1, JAK2, and tyrosine kinase 2 (TYK2; IC50s = 770, 3,850, and 2,310 nM, respectively), but also inhibits JAK3 (IC50 = 17 nM).{67060},{67061} PKCβ inhibitor (14 µM) induces apoptosis and inhibits cell cycle progression in 2F7 AIDS-related Burkitt’s lymphoma cells.{67062}

• SKU: CAY35494-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35494-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: Reinstoffe