PKM2 Inhibitor, CAS 94164-88-2

Formulation: A solid

Formal Name: 1-piperidinecarbodithioic acid, (1,4-dihydro-3-methyl-1,4-dioxo-2-naphthalenyl)methyl ester

Purity: ≥98%

Formula Markup: C18H19NO2S2

Formula Weight: 345,5

Shelf life (days): 1460

CAS Number: 94164-88-2

Notes: PKM2 inhibitor is an inhibitor of pyruvate kinase M2 (PKM2; IC50 = 2.95 µM), a tumor-specific kinase with a role in glycolysis.{66172} It is selective for PKM2 over PKM1 and L-type pyruvate kinase (PKLR; IC50s = 16.71 and 8.2 µM, respectively). PKM2 inhibitor is cytotoxic to HCT116, HeLa, and H1299 cells (IC50s = 0.18, 0.29, and 1.56 µM, respectively). It induces apoptosis and autophagy in SKOV3 ovarian cancer cells when used at concentrations of 1, 2.5, and 5 µM.{66173} In vivo, PMK2 inhibitor (5 mg/kg) reduces tumor volume and weight in an SKOV3 mouse xenograft model.

• SKU: CAY36815-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36815-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK
• Application: Reinstoffe