Product Description: Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM[1].
Formula: C31H32N6O2
Citations: Life Sci. 2023 Jul 29;329:121990./Arthritis Res Ther. 2024 Jan 25;26(1):36./Biochem Biophys Res Commun. 12 August 2021./Burns Trauma. 2019 Sep 23;7:29./Cancer Med. 2018 Nov;7(11):5704-5715./Int J Mol Sci. 2024 Apr 9, 25(8), 4138./J Exp Clin Cancer Res. 2018 Nov 27;37(1):287. /Med Oncol. 2021 Mar 17;38(4):41./Mil Med Res. 2020 Nov 1;7(1):52./Mil Med Res. 2020 Sep 6;7(1):42. /Oncol Lett. 2019 Sep;18(3):3081-3091./Patent. US20180263995A1./Pharmacol Res. 2021 Jan 26;105460.
References: [1]Karumbayaram S, et al. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells. 2009 Apr;27(4):806-11. /[2]Hu Y, et al. Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells. J Neurosci Methods. 2016 Jun 15;266:42-9. /[3]Hua T, et al. Phenotypic, metabolic, and biogenesis properties of human stem cell-derived cerebellar spheroids. Sci Rep. 2022 Jul 27;12(1):12880. /[4]Sharma R, et al. 3D Bioprinting Pluripotent Stem Cell Derived Neural Tissues Using a Novel Fibrin Bioink Containing Drug Releasing Microspheres. Front Bioeng Biotechnol. 2020 Feb 11;8:57. /[5]Sundberg M, et al. Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells. 2013 Aug;31(8):1548-62.
CAS Number: 483367-10-8
Molecular Weight: 520.62
Research Area: Neurological Disease; Cancer
Solubility: 10 mM in DMSO
Target: Smo
English
Deutsch
