PYR-41 , CAS 418805-02-4

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Applications: Useful for inhibition of E1 ubiquitin conjugating enzymes

CAS Number: 418805-02-4

Description: PYR-41 is a cell permeable, irreversible inhibitor of ubiquitin activating enzyme E1 with little or no activity against E2s or E3s (IC50 < 10 µM). It blocks degradation of p53 and inhibits NF-κappaB-dependent pathways. PYR-41 also increases SUMOylation of proteins.

Format: Brown powder

Purity: >98% by TLC.

Solubility: Soluble in DMSO (100 mM)

Storage Stability: Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 week.

Warnings: Protect from light. Protect from moisture. Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Yang et al (2007). Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res. 67:9472.
2. Mi et al (2009). Cancer preventative isothiocyanates induce selective degradation of cellular ?- and ?-tubulins by proteasomes. J. Biol. Chem. 284:17039.
3. Brahemi et al (2010). Homology modelling of human E1 ubiquitin activating enzyme. Lett. Drug Des. Discov. 7:57.

• SKU: BPS27716-2
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 27716-2
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK