Pyrotinib (maleate), CAS 1397922-61-0

Formulation: A solid

Formal Name: (2E)-N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methyl-2-pyrrolidinyl]-2-propenamide, (2Z)-2-butenedioate

Purity: ≥98%

Formula Markup: C32H31ClN6O3 • 2C4H4O4

Formula Weight: 815,2

Shelf life (days): 1460

CAS Number: 1397922-61-0

Notes: Pyrotinib is an inhibitor of EGFR and HER2 (IC50s = 13 and 38 nM, respectively).{69984} It selectively inhibits the proliferation of HER2-positive BT474 breast and SKOV3 ovarian cancer cells (IC50s = 5.1 and 43 nM, respectively) over HER2-negative MDA-MB-231 breast cancer cells (IC50 = 3,500 nM). In vivo, pyrotinib (10 mg/kg per day) decreases tumor growth without affecting body weight in BT474 and SKOV3 mouse xenograft models.

• SKU: CAY42108-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42108-1
• Package Unit: 1 mg
• Quantity Unit: STK