Products from BPS Bioscience require a minimum order value above 400€
Biological Activity: (R)-MG132 inhibits ChTL, TL and PGPH with IC50 values of 0.22 µM, 34.4 µM, and 2.95 µM, respectively.
CAS Number: 1211877-36-9
Description: (R)-MG132 is a potent, cell permeable and reversible inhibitor of proteasomes. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. In comparison to (S)-MG132, the (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities.
Format: A crystalline solid
Purity: ≥97%
Solubility: Soluble in ethanol, DMSO and DMF, purged with an inert gas. Solubility in thesesolvents is approximately 25 mg/ml
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Lee, D.H., et al., Trends Cell Biol. 1998;8:397-403
2. Elliot, P.J., et al., J. Mol. Med. 2003;81:235-245
3. Mroczkiewicz, M., et al., J. Med. Chem. 2010;53:1509-1518.
English
Deutsch
