Formulation: A crystalline solid
Formal Name: 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
Purity: ≥98%
Formula Markup: C24H16F6N6O
Formula Weight: 518,4
Shelf life (days): 1460
CAS Number: 927880-90-8
Notes: RAF265 is a dual inhibitor of mutant B-RafV600E and vascular endothelial growth factor receptor 2 (EC50s = 0.14 and 0.19 µM, respectively, in cell-based assays).{27852} It can also inhibit wild-type B-Raf, platelet-derived growth factor receptor, colony-stimulating factor 1R, RET, c-KIT, SRC, and STE20 with IC50 values ranging from 20-100 nM.{27957} RAF265 can inhibit proliferation of melanoma and colorectal cancer cell lines with active BRAF mutations as well as suppress tumor growth in melanoma xenograft models bearing B-RafV600E mutations.{27957}
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