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Background: RepSox is a TGF-βI receptor kinase inhibitor, that can replace SOX2 (SRY-box 2) during the reprogramming of adult cells into iPS (induced pluripotent) cells, by inducing transcription of Nanog. It also supports RPE (retinal pigmented epithelium) differentiation from iPS cells, increasing the expression of epithelial markers, RPE-specific genes and supporting cell viability in 3D cultures. In addition, it was proposed that RepSox could be useful as therapeutic for obesity and type 2 diabetes, as RepSox alone was sufficient to promote differentiation of brown fat precursor cells and browning of white fat, which have been considered as treatment strategies for those disorders. Its application may extend to the treatment of OS (osteosarcoma), as it was able to induce S-phase cell arrest and apoptosis of OS cell line models, and in vivo xenograft models. RepSox is thus a molecule of high interest in multiple research fields.
CAS Number: 446859-33-2
Description: RepSox is an inhibitor of TGF-β type I receptor (ALK5). RepSox can reprogram adult cells into pluripotent stem cells via induction of Nanog transcription.
Purity: ≥99% by HPLC
Storage Stability: Upon receipt, store at -20°C. Stable for 1 year from date of receipt, when stored as directed. Solutions are stable for up to 1 month at -20°C.
Supplied As: Solid
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
References: Ichida J., et al., 2009 Cell Stem Cell 5(5):491-503.
Want W., et al., 2024 Journal of Biological Engineering 18:7.
Tu W., et al., 2019 Acta Pharmacologica Sinica 40:1523-1531.
He W., et al., 2021 Int J Oncol 59(5):84.
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