RG3039, CAS 1005504-62-0

Formulation: A solid

Formal Name: 5-[[1-[(2,6-dichlorophenyl)methyl]-4-piperidinyl]methoxy]-2,4-quinazolinediamine

Purity: ≥98%

Formula Markup: C21H23Cl2N5O

Formula Weight: 432,4

Shelf life (days): 1460

CAS Number: 1005504-62-0

Notes: RG3039 is an inhibitor of mRNA decapping scavenger enzyme (DcpS; IC50 = 0.069 nM).{65258} It prevents denervation of the neuromuscular junction (NMJ) and decreases in NMJ synaptic transmission and myofiber size of the longissimus muscle in a mouse model of spinal muscular atrophy (SMA) induced by knockout of the gene encoding survival motor neuron 1 (Smn1) when administered at a dose of 10 mg/kg.{65259} RG3039 improves survival and motor function in the same model.

• SKU: CAY36589-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36589-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK
• Application: Reinstoffe