Formulation: A solid
Formal Name: 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98%
Formula Markup: C27H30O14
Formula Weight: 578,5
Shelf life (days): 1460
CAS Number: 17306-46-6
Notes: Rhoifolin is a flavonoid glycoside that has been found in C. nudiflora and has diverse biological activities.{61920,61921,61922,61923,61924} It inhibits Ezrin phosphorylation, cell migration, and TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in MDA-MB-231 cells when used at concentrations of 10 and 40 µM.{61920} Rhoifolin inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro; IC50 = 27.45 µM).{61921} It reverses scopolamine-induced memory deficits and inhibits acetylcholinesterase (AChE) activity in zebrafish when administered in the tank water at concentrations of 1, 3, and 5 µg/L.{61922} Rhoifolin (20 and 40 mg/kg) reduces paw edema and IL-1β, IL-6, and TNF-α levels in a rat model of carrageenan-induced inflammation.{61923} It also ameliorates cartilage damage in a rat model of osteoarthritis, an effect that can be reversed by the autophagy inhibitor 3-methyladenine (Item No. 13242).{61924}
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