Rocilinostat (ACY-1215), CAS 1316214-52-4

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CAS Number: 1316214-52-4

Description: Rocilinostat, also known as ACY-1215, is a selective HDAC6 inhibitor with IC50 of 5 nM. It is over 10-fold more selective for HDAC6 than HDAC1, 2, 3 (class I HDACs) with slight activity against HDAC8, and minimal activity against HDAC4, 5, 7, 9, 11, SIRT1, and SIRT2.

Purity: ≥99% by HPLC

Solubility: Soluble in DMSO

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Target: HDAC6

Biosafety Level: Not applicable (BSL-1)

References: 1. Mithraprabhu S, et al. Br J Haematol. 2013 Aug;162(4):559-62. doi: 10.1111/bjh.12388.
2. Santo L, et al. Blood. 2012 Mar 15;119(11):2579-89.

• SKU: BPS27644-2
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 27644-2
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK