Formulation: A solid
Formal Name: (1S)-2-amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
Purity: ≥95%
Formula Markup: C18H20N4O2
Formula Weight: 324,4
Shelf life (days): 1460
CAS Number: 2719793-90-3
Notes: RP 6306 is an inhibitor of membrane-associated tyrosine- and threonine-specific Cdc2-inhibitory kinase (Myt1 kinase), also known as PKMYT1 (IC50 = 0.002 nM in a bioluminescence resonance energy transfer (BRET) assay).{69970} It is greater than 29-fold selective for Myt1 kinase over eight other kinases in BRET assays at 1.2 µM. RP 6306 (500 nM) increases the levels of DNA-associated γ histone H2AX (γH2AX), a marker of DNA damage, in hTERT FT 282 fallopian tube cells.{69971} It induces cell cycle arrest at the S phase in hTERT FT 282 cells. Dietary administration of RP 6306 (15, 50, or 300 ppm) reduces tumor volume in an OVCAR-3 ovarian cancer mouse xenograft model.{69970}
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