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CAS Number: 1092939-17-7
Description: Ruxolitinib, also known as INCB18424, is a potent and selective Janus kinase JAK1 and JAK2 inhibitor, with IC50s of 5.9 nM and 5.7 nM, respectively. It inhibited IL-6 and IL-23 effects at concentrations less than 50 nM. Ruxolitinib was effective in the rat adjuvant arthritis model and multiple murine models of arthritis.
Format: white powder.
Purity: ≥99%
Solubility: Soluble in DMSO at 200 mg/ml; very poorly soluble in ethanol; soluble in water at 8 mg/ml
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: Fridman, J.S., et al. J. Immunol. 184: 5298-5307 (2010).
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