Formulation: A solid
Formal Name: 4-[(2-phenylethyl)amino]-6-quinazolinecarbonitrile
Purity: ≥98%
Formula Markup: C17H14N4
Formula Weight: 274,3
Shelf life (days): 1460
CAS Number: 1366002-50-7
Notes: Senexin A is an inhibitor of cyclin-dependent kinase 8 (Cdk8; IC50 = 0.28 µM).{65969} It also inhibits cyclin-dependent kinase inhibitor p21WAF1-induced reporter expression in reporter assay using HT-1080 p21-9 cells (IC50 = 0.68 µM). Senexin A (2.5 µM) prevents 17β-estradiol-induced increases in expression of mRNA encoding gene regulated in breast cancer 1 (GREB1), chemokine (C-X-C motif) ligand 12 (CXCL12), and trefoil factor 1 (TFF1) in estrogen-deprived MCF-7, BT474, and T47D breast cancer cells.{42923} It decreases intracellular and extracellular viral RNA, the number of infectious particles, as well as dengue virus-induced increases in the levels of mRNA encoding LC3-II in dengue virus-infected Huh7 cells when used at a concentration of 25 µM.{65970} Senexin A (12.5 µM) reduces mitochondrial oxygen consumption rate (OCR) and increases glycolysis in uninfected and dengue virus-infected Huh7 cells.
English
Deutsch
