SGC6870, CAS 2561471-27-8

Formulation: A solid

Formal Name: 4-[(5R-bromo-2-thienyl)carbonyl]-5-(3,5-dimethylphenyl)-1,3,4,5-tetrahydro-7-methyl-2H-1,4-benzodiazepin-2-one

Purity: ≥98%

Formula Markup: C23H21BrN2O2S

CAS Number: 2561471-27-8

Notes: SGC6870 is an inhibitor of protein arginine methyltransferase 6 (PRMT6; IC50 = 77 nM).{51801} It is selective for PRMT6 over a panel of 76 methyltransferases, G protein-coupled receptors (GPCRs), ion channels, receptors, and other enzymes at 1 µM. SGC6870 decreases the levels of dimethylated arginine 2 on histone 3 (H3R2me2) and dimethylated arginine 3 on histone 4 (H4R3me2) in HEK293T cells (IC50s = 0.9 and 0.6 µM, respectively). See the Structural Genomics Consortium (SGC) website for more information.

• SKU: CAY33712-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 33712-1
• Package Unit: 1 mg
• Quantity Unit: STK