SHIN 1, CAS 2146095-85-2

Formulation: A solid

Formal Name: 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1′-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-pyrano[2,3-c]pyrazole-5-carbonitrile

Purity: ≥98%

Formula Markup: C24H24N4O2

Formula Weight: 400,5

Shelf life (days): 1460

CAS Number: 2146095-85-2

Notes: SHIN 1 is an inhibitor of serine hydroxymethyltransferase 1 (SHMT1) and SHMT2 (IC50s = 5 and 13 nM, respectively).{66156} It inhibits proliferation of H1299 non-small cell lung cancer (NSCLC) cells overexpressing the proto-oncogene FRAT1 (IC50 = 0.6 µM). SHIN 1 decreases tumor volume in an NSCLC mouse xenograft model using FRAT1-overexpressing H1299 cells when administered at a dose of 100 mg/kg three times a week.

• SKU: CAY35715-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35715-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe