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Biological Activity: Sildenafil was developed in 1998 as the first selective PDE-5 inhibitor with IC50 of 3.5 nM.
CAS Number: 171599-83-0
Description: Sildenafil citrate, also known as Revatio, acts by inhibiting cGMP specific phosphodiesterase type 5 (PDE5). The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5.
Format: White to off-white solid.
Purity: ≥99% by HPLC
Solubility: Soluble in water at 3.5 mg/ml. Soluble in DMSO to 100 mM
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Warnings: Hygroscopic. Protect from moisture.
Biosafety Level: Not applicable (BSL-1)
References: Muneer, A. et al. US Endocrine Disease (2007); 1:92-95.