Formulation: A solid
Formal Name: (3R,3aR,6R,7aR,8R)-4-[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3,6-methanobenzofuran-7(6H)-one
Purity: ≥95%
Formula Markup: C25H22O10
Formula Weight: 482,4
Shelf life (days): 1460
CAS Number: 29782-68-1
Notes: Silydianin is a flavonolignan that has been found in S. marianum and has diverse biological activities.{46261,51587,51588,51589} It inhibits tyrosinase (IC50 = 2.6 µM for the mushroom enzyme) and scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC50 = 66.8 µM).{46261,51587} Silydianin (100 µM) protects against cytotoxicity induced by allyl alcohol, carbon tetrachloride, paracetamol (acetaminophen; Item No. 10024), or D-galactosamine (Item No. 22981) in primary human hepatocytes.{51587} It inhibits the proliferation of DU145 and PC3 prostate cancer cells when used at a concentration of 90 µM.{51588} Silydianin (1%) prevents methacholine-induced airway hyperresponsiveness (AHR) and reduces blood and bronchoalveolar lavage fluid (BALF) levels of eosinophils in an ovalbumin-sensitized mouse model of allergic asthma when administered via inhalation.{51589}
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