Formulation: A solid
Formal Name: 3-(4-hydroxy-3,5-dimethoxyphenyl)-2E-propenal
Purity: ≥98%
Formula Markup: C11H12O4
Formula Weight: 208,2
Shelf life (days): 1460
CAS Number: 4206-58-0
Notes: Sinapaldehyde is a phenylpropanoid that has been found in A. altissima and has diverse biological activities.{61320,72273,72274,72275,72276,72277} It is an intermediate in the biosynthesis of the monolignol sinapyl alcohol (Item No. 33916) in angiosperms.{72273} Sinapaldehyde is an inhibitor of farnesyltransferase (FTase; IC50 = 23.99 µM for the rat enzyme).{72274} It inhibits TNF-α-induced NF-κB transcriptional activity in a reporter assay using HepG2 cells (IC50 = 13.25 µM) and reduces LPS-induced nitric oxide (NO) production in RAW 264.7 cells (IC50 = 5.92 µM).{61320,72275} Sinapaldehyde scavenges DPPH (Item No. 14805) and ABTS (Item No. 27317) radicals in cell-free assays (IC50s = 83.02 and 43.15 µM, respectively).{72276} It is active against the Gram-positive bacteria P. pseudomonas, E. coli, and S. enterica (MICs = 64, 128, and 128 µg/ml, respectively) and the Gram-negative bacteria B. cereus, methicillin-sensitive S. aureus (MSSA), and methicillin-resistant S. aureus (MRSA; MICs = 128, 64, and 128 µg/ml, respectively).{72277} It also inhibits α-glucosidase with an IC50 value of 98.81 µM.{72276}
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