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Background: Unlike TSA, Sirtinol does not inhibit class I and class II HDACs, indicating that it is a selective sirtuin inhibitor. The downregulation of SIRT1/2 expression plays an important role in the regulation of breast cancer apoptosis; thus, SIRT1/2 may be a novel molecular target for cancer therapy.
CAS Number: 410536-97-9
Description: Cell-permeable, selective sirtuin inhibitor that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.
Purity: ≥98% by HPLC
Solubility: DMSO 23 mg/ml, Water <1 mg/ml, Ethanol <1 mg/ml
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: SIRT1, SIRT2
Biosafety Level: Not applicable (BSL-1)
References: 1. Wang J,et al. Int J Oncol. 2012 Sep;41(3):1101-9.
2. Grozinger CM, et al. J Biol Chem. 2001 Oct 19;276(42):38837-43.
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