Formulation: A solid
Formal Name: 2-phenyl-naphth[2,3-d]oxazole-4,9-dione
Purity: ≥98%
Formula Markup: C17H9NO3
Formula Weight: 275,3
Shelf life (days): 1460
CAS Number: 63388-44-3
Notes: SJB2-043 is an inhibitor of the ubiquitin-specific peptidase 1 (USP1) and USP1-associated factor 1 (UAF1) complex (USP1-UAF1 complex; IC50 = 0.544 µM for its deubiquitinase activity) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) papain-like protease (PLpro).{36957,66108} It reduces the levels of USP1, DNA-binding protein inhibitor 1 (ID-1), ID-2, and ID-3 in K562 chronic myelogenous leukemia (CML) cells when used at concentrations ranging from 0.5 to 10 µM, an effect that can be partially blocked by the proteasome inhibitor MG132.{36957} SJB2-043 decreases the viability of K562 cells (EC50 = 1.07 µM) and induces apoptosis in K562 cells in a concentration-dependent manner. It also inhibits SARS-CoV-2 PLpro with IC50 values of 0.56 and 0.091 µM using the fluorogenic substrates Z-LRGG-AMC (Item No. 26641) or ubiquitin-AMC (Ub-AMC), respectively, as PLpro substrates.{66108}
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